Narrow-sense heritability estimation of complex traits using identity-by-descent information.

ABSTRACT: Heritability is a fundamental parameter in genetics. Traditional estimates based on family or twin studies can be biased due to shared environmental or non-additive genetic variance. Alternatively, those based on genotyped or imputed variants typically underestimate narrow-sense heritability contributed by rare or otherwise poorly tagged causal variants. Identical-by-descent (IBD) segments of the genome share all variants between pairs of chromosomes except new mutations that have arisen since the last common ancestor. Therefore, relating phenotypic similarity to degree of IBD sharing among classically unrelated individuals is an appealing approach to estimating the near full additive genetic variance while possibly avoiding biases that can occur when modeling close relatives. We applied a

SUBMITTER: Evans LM 

PROVIDER: S-EPMC6221881 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature