The IICR and the non-stationary structured coalescent: towards demographic inference with arbitrary changes in population structure.

ABSTRACT: In the last years, a wide range of methods allowing to reconstruct past population size changes from genome-wide data have been developed. At the same time, there has been an increasing recognition that population structure can generate genetic data similar to those produced under models of population size change. Recently, Mazet et al. (Heredity 116:362-371, 2016) showed that, for any model of population structure, it is always possible to find a panmictic model with a particular function of population size changes, having exactly the same distribution of T₂ (the coalescence time for a sample of size two) as that of the structured model. They called this function IICR (Inverse Instantaneous Coalescence Rate) and showed that it does not necessarily correspond to population size

SUBMITTER: Rodriguez W 

PROVIDER: S-EPMC6221895 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature