Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study.

ABSTRACT:

Background

Inorganic arsenic exposure and inter-individual differences in its metabolism have been associated with cardiometabolic risk. A more efficient arsenic metabolism profile (lower MMA%, higher DMA%) has been associated with reduced risk for arsenic-related health outcomes; however, this profile has also been associated with increased risk for diabetes-related outcomes. The mechanism behind these contrasting associations is equivocal; we hypothesized one carbon metabolism (OCM) may play a role.

Methods

We evaluated the association between OCM-related variables (nutrient intake and genetic variants) and both arsenic metabolism biomarkers (iAs%, MMA% and DMA%) and diabetes-related outcomes (metabolic syndrome, diabetes, HOMA2-IR and waist circumference) in 935 participa

SUBMITTER: Spratlen MJ 

PROVIDER: S-EPMC6221918 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature