CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma.

ABSTRACT:

Purpose

Prior research in animal models has shown that macrophages and microglia play an important role in pathogenesis of glaucoma, but the phenotype and distribution of macrophages in human glaucomatous tissue have not been sufficiently characterized.

Methods

We analyzed H&E, CD68-, and CD163-immunostained slides from 25 formaldehyde-fixed, paraffin-embedded autopsy eyes: 12 control eyes and 13 eyes with glaucoma. The diagnosis of glaucoma was made based on a history of glaucoma as reported in the medical record and histological changes characteristic of glaucoma. Glaucoma cases and controls were matched in terms of age, sex, and race.

Results

Qualitative analysis of the conventional outflow pathway and the optic nerve revealed that all eyes contained CD163+ cells b

SUBMITTER: Margeta MA 

PROVIDER: S-EPMC6221945 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature