Dendritic Cells Are Critical for the Activation and Expansion of Vδ2⁺ T Cells After Allogeneic Hematopoietic Transplantation.

ABSTRACT: γδ T cells perform antitumor and antiviral effector functions and are involved in both innate and adaptive immunity. Vδ2⁺ T cells represent the predominant γδ T subset in the peripheral blood of healthy subjects. Vδ2⁺ T cells can be selectively activated and expanded by phosphoantigens (pAgs). Dendritic cells (DCs), as potent antigen-presenting cells, are capable of mediating pAgs-triggered Vδ2⁺ T cells expansion. However, the association between DCs and Vδ2⁺ T cell recovery in the context of hematopoietic stem cell transplantation (HSCT) remains unclear. We previously demonstrated that the recovery of Vδ2⁺ T cells was hampered and inversely correlated with Epstein-Barr virus (EBV) reactivation in patients undergoing haploidentical HSC

SUBMITTER: Wang X 

PROVIDER: S-EPMC6221956 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature