Dibutyl-phthalate exposure from mesalamine medications and serum thyroid hormones in men.

ABSTRACT:

Background

Dibutyl phthalate (DBP) is an endocrine disruptor and used in some medication coatings, such as mesalamine for treatment inflammatory bowel disease (IBD).

Objectives

To determine whether high-DBP from some mesalamine medications alters thyroid function.

Methods

Seventy men with IBD, without thyroid disease or any radiation history participated in a crossover-crossback prospective study and provided up to 6 serum samples (2:baseline, 2:crossover, 2:crossback). Men on non-DBP mesalamine (background exposure) at baseline crossed-over to DBP-mesalamine (high exposure) then crossed-back to non-DBP mesalamine (B₁HB₂-arm) and vice versa for men on DBP-mesalamine at baseline (H₁BH₂-arm). Serum concentrations of total trii

SUBMITTER: Nassan FL 

PROVIDER: S-EPMC6221978 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature