Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration.

ABSTRACT: Bone metastasis is a leading cause of death in patients with breast cancer, but the underlying mechanisms are poorly understood. While much work focuses on the molecular and cellular events that drive breast cancer bone metastasis, it is mostly unclear what role bone extracellular matrix (ECM) properties play in this process. Bone ECM primarily consists of mineralized collagen fibrils, which are composed of non-stoichiometric carbonated apatite (HA) and collagen type I. Reduced bone mineral content is epidemiologically linked with increased risk of bone metastasis. Yet elucidating the potential functional impact of collagen mineralization on breast cancer cells has remained challenging because of a lack of model systems that allow studying tumor cell behavior as a function of physiological

SUBMITTER: Choi S 

PROVIDER: S-EPMC6222013 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature