Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls.

ABSTRACT: Transcription at enhancers is a widespread phenomenon which produces so-called enhancer RNA (eRNA) and occurs in an activity-dependent manner. However, the role of eRNA and its utility in exploring disease-associated changes in enhancer function, and the downstream coding transcripts that they regulate, is not well established. We used transcriptomic and epigenomic data to interrogate the relationship of eRNA transcription to disease status and how genetic variants alter enhancer transcriptional activity in the human brain. We combined RNA-seq data from 537 postmortem brain samples from the CommonMind Consortium with cap analysis of gene expression and enhancer identification, using the assay for transposase-accessible chromatin followed by sequencing (ATACseq). We find 118 differentially

SUBMITTER: Hauberg ME 

PROVIDER: S-EPMC6222027 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature