In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease.

ABSTRACT:

Introduction

The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear.

Methods

We estimated cortical thickness, tau ([¹⁸F]-AV-1451), and amyloid β (Aβ) status ([¹¹C]-PiB) in 47 subjects who were stratified into Aβ- (14 healthy controls and six mild cognitive impairment-Aβ-) and Aβ+ (14 mild cognitive impairment-Aβ+ and 13 AD) groups.

Results

Compared with the Aβ- group, tau was increased in widespread regions whereas cortical thinning was restricted to the temporal cortices. Increased tau binding was associated with cortical thinning in each Aβ group. Locally, regional tau wa

SUBMITTER: Mak E 

PROVIDER: S-EPMC6222030 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature