The Enterococcus Cassette Chromosome, a Genomic Variation Enabler in Enterococci.

ABSTRACT: Enterococcus faecium has a highly variable genome prone to recombination and horizontal gene transfer. Here, we have identified a novel genetic island with an insertion locus and mobilization genes similar to those of staphylococcus cassette chromosome elements SCCmec This novel element termed the enterococcus cassette chromosome (ECC) element was located in the 3' region of rlmH and encoded large serine recombinases ccrAB similar to SCCmec Horizontal transfer of an ECC element termed ECC::cat containing a knock-in cat chloramphenicol resistance determinant occurred in the presence of a conjugative rep_pLG1 plasmid. We determined the ECC::cat insertion site in the 3' region of rlmH in the E. faecium reci

SUBMITTER: Sivertsen A 

PROVIDER: S-EPMC6222049 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature