Slow activation of fast mitochondrial Ca²⁺ uptake by cytosolic Ca².

ABSTRACT: Mitochondrial Ca²⁺ uptake through the mitochondrial Ca²⁺ uniporter (MCU) is a tightly controlled process that sustains cell functions mainly by fine-tuning oxidative metabolism to cellular needs. The kinetics of Ca²⁺ fluxes across the mitochondrial membranes have been studied both in vitro and in vivo for many years, and the discovery of the molecular components of the MCU has further clarified that this Ca²⁺ uptake mechanism is based on a complex system subject to elaborate layers of controls. Alterations in the speed or capacity of the in-and-out pathways can have detrimental consequences for both the organelle and the cell, impairing cellular metabolism and ultimately causing cell death. Here, we report that pretreatment of deene

SUBMITTER: Basso E 

PROVIDER: S-EPMC6222101 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature