Oxidative cyclization of <i>N</i>-methyl-dopa by a fungal flavoenzyme of the amine oxidase family.

ABSTRACT: Flavin-dependent enzymes catalyze many oxidations, including formation of ring structures in natural products. The gene cluster for biosynthesis of fumisoquins, secondary metabolites structurally related to isoquinolines, in the filamentous fungus Aspergillus fumigatus harbors a gene that encodes a flavoprotein of the amine oxidase family, termed fsqB (fumisoquin biosynthesis gene B). This enzyme catalyzes an oxidative ring closure reaction that leads to the formation of isoquinoline products. This reaction is reminiscent of the oxidative cyclization reported for berberine bridge enzyme and tetrahydrocannabinol synthase. Despite these similarities, amine oxidases and berberine bridge enzyme-like enzymes possess distinct structural properties, prompting us to investigate the s

SUBMITTER: Lahham M 

PROVIDER: S-EPMC6222107 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature