Gut Microbial and Metabolic Responses to Salmonella enterica Serovar Typhimurium and Candida albicans.

ABSTRACT: The gut microbiota confers resistance to pathogens of the intestinal ecosystem, yet the dynamics of pathogen-microbiome interactions and the metabolites involved in this process remain largely unknown. Here, we use gnotobiotic mice infected with the virulent pathogen Salmonella enterica serovar Typhimurium or the opportunistic pathogen Candida albicans in combination with metagenomics and discovery metabolomics to identify changes in the community and metabolome during infection. To isolate the role of the microbiota in response to pathogens, we compared mice monocolonized with the pathogen, uninfected mice "humanized" with a synthetic human microbiome, or infected humanized mice. In Salmonella-infected mice, by 3 days into infection, microbiome community structure and

SUBMITTER: Bratburd JR 

PROVIDER: S-EPMC6222126 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature