Manganese-Enhanced T₁ Mapping in the Myocardium of Normal and Infarcted Hearts.

ABSTRACT:

Background

Manganese-enhanced MRI (MEMRI) has the potential to identify viable myocardium and quantify calcium influx and handling. Two distinct manganese contrast media have been developed for clinical application, mangafodipir and EVP1001-1, employing different strategies to mitigate against adverse effects resulting from calcium-channel agonism. Mangafodipir delivers manganese ions as a chelate, and EVP1001-1 coadministers calcium gluconate. Using myocardial T₁ mapping, we aimed to explore chelated and nonchelated manganese contrast agents, their mechanism of myocardial uptake, and their application to infarcted hearts.

Methods

T₁ mapping was performed in healthy adult male Sprague-Dawley rats using a 7T MRI scanner before and after nonchelated (EVP1

SUBMITTER: Spath NB 

PROVIDER: S-EPMC6222240 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature