Genetic polymorphisms of matrix metalloproteinases 1-3 and their inhibitor are not associated with premature labor.

ABSTRACT:

Aim

Extracellular matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of metalloproteinases [TIMPs]) are involved in the breakdown of fetal membranes before delivery. Our aim was to investigate the occurrence of any polymorphism on genes coding for MMPs 1-3 and TIMP 2 in preterm laboring patients as a potential source of this phenomenon. This question has not been studied before.

Methodology & results

A prospective population study was performed in a Greek university hospital. Group A (control) included 66 women with no symptoms of premature labor. Group B (research) comprised 66 women, exhibiting signs of threatened preterm labor. No statistically significant difference in polymorphism, both in the distribution of genotype as well as allel

SUBMITTER: Lathouras K 

PROVIDER: S-EPMC6222277 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature