Periodontal regeneration with autologous periodontal ligament-derived cell sheets - A safety and efficacy study in ten patients.

ABSTRACT:

Background

Periodontitis results in the destruction of tooth-supporting periodontal tissues and does not have the ability to heal spontaneously. Various approaches have been introduced to regenerate periodontal tissues; however, these approaches have limited efficacy for treating severe defects. Cytotherapies combine stem cell biology and tissue engineering to form a promising approach for overcoming these limitations. In this study, we isolated periodontal ligament (PDL)-derived cells from patients and created cell sheets with "Cell Sheet Engineering Technology", using temperature responsive culture dishes, in which all the cultured cells can be harvested as an intact transplantable cell sheet by reducing the temperature of the culture dish. Subsequently, the safety and efficacy o

SUBMITTER: Iwata T 

PROVIDER: S-EPMC6222282 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature