A Promising Copper(II) Complex as Antifungal and Antibiofilm Drug against Yeast Infection.

ABSTRACT: The high mortality rate of candidemia and the limited option for the treatment of Candida spp. infection have been driving the search for new molecules with antifungal property. In this context, coordination complexes of metal ions and ligands appear to be important. Therefore, this study aimed to synthesize two new copper(II) complexes with 2-thiouracil and 6-methyl-2-thiouracil ligands and to evaluate their mutagenic potential and antifungal activity against Candida. The complexes were synthesized and characterized by infrared vibrational spectroscopy, CHN elemental analysis, UV-Vis experiments and ESI-HRMS spectrometry studies. The antifungal activity was evaluated by broth microdilution against 21 clinical isolates of Candida species. The mutagenic potential was ev

SUBMITTER: Gomes da Silva Dantas F 

PROVIDER: S-EPMC6222317 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature