Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease.

ABSTRACT: Alzheimer's disease still represents an untreated multifaceted pathology, and drugs able to stop or reverse its progression are urgently needed. In this paper, a series of naturally inspired chalcone-based derivatives were designed as structural simplification of our previously reported benzofuran lead compound, aiming at targeting both acetyl (AChE)- and butyryl (BuChE) cholinesterases that, despite having been studied for years, still deserve considerable attention. In addition, the new compounds could also modulate different pathways involved in disease progression, due to the peculiar trans-α,β-unsaturated ketone in the chalcone framework. All molecules presented in this study were evaluated for cholinesterase inhibition on the human enzymes and for antioxidant and neuroprotecti

SUBMITTER: Rampa A 

PROVIDER: S-EPMC6222323 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature