Synthesis, Antifungal Activities and Molecular Docking Studies of Benzoxazole and Benzothiazole Derivatives.

ABSTRACT: Based on benzoxazole and benzothiazole scaffold as an important pharmacophore, two series of 2-(aryloxymethyl) benzoxazole and benzothiazole derivatives were synthesized and their antifungal effects against eight phytopathogenic fungi were evaluated. Compounds 5a, 5b, 5h, and 5i exhibited significant antifungal activities against most of the pathogens tested. Especially 5a, 5b, 5h, 5i, 5j, and 6h inhibited the growth of F. solani with IC₅₀ of 4.34⁻17.61 μg/mL, which were stronger than that of the positive control, hymexazol (IC₅₀ of 38.92 μg/mL). 5h was the most potent inhibitor (IC₅₀ of 4.34 μg/mL) against F. Solani, which was about nine times more potent than hymexa

SUBMITTER: Luo B 

PROVIDER: S-EPMC6222379 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature