Meliacarpinin-Type Limonoids from the Bark of Melia toosendan.

ABSTRACT: Three new meliacarpinin-type limonoids, toosendanes A⁻C (1⁻3), along with three, known meliacarpinins (4⁻6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, modified Mosher's method, and electronic circular dichroism (ECD). Limonoids 2 and 3 showed moderate inhibitory activity on LPS-activated, RAW 264.7 macrophages.

SUBMITTER: Hu Y 

PROVIDER: S-EPMC6222421 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature