A Case Study of Genomic Instability in an Industrial Strain of Saccharomyces cerevisiae.

ABSTRACT: The Saccharomyces cerevisiae strain JAY270/PE2 is a highly efficient biocatalyst used in the production of bioethanol from sugarcane feedstock. This strain is heterothallic and diploid, and its genome is characterized by abundant structural and nucleotide polymorphisms between homologous chromosomes. One of the reasons it is favored by many distilleries is that its cells do not normally aggregate, a trait that facilitates cell recycling during batch-fed fermentations. However, long-term propagation makes the yeast population vulnerable to the effects of genomic instability, which may trigger the appearance of undesirable phenotypes such as cellular aggregation. In pure cultures of JAY270, we identified the recurrent appearance of mutants displaying a mother-daughter cell separation

SUBMITTER: Rodrigues-Prause A 

PROVIDER: S-EPMC6222563 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature