tert-Butylphenolic Derivatives from Paenibacillus odorifer-A Case of Bioconversion.

ABSTRACT: Two compounds (1) and (2) containing tert-butylphenol groups were, for the first time, produced during the culture of Paenibacillus odorifer, a bacterial strain associated with the crustose lichen, Rhizocarpon geographicum. Their entire structures were identified by one-dimensional (1D) and two-dimensional (2D) NMR and high-resolution electrospray ionisation mass spectrometry (HRESIMS) spectroscopic analyses. Among them, Compound 1 exhibited significant cytotoxicity against B16 murine melanoma and HaCaT human keratinocyte cell lines with micromolar half maximal inhibitory concentration (IC₅₀) values. Furthermore, after supplementation studies, a putative biosynthesis pathway was proposed for Compound 1 throughout a bioconversion b

SUBMITTER: Nguyen TB 

PROVIDER: S-EPMC6222599 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature