Anti-Inflammatory, Anti-Diabetic, and Anti-Alzheimer's Effects of Prenylated Flavonoids from Okinawa Propolis: An Investigation by Experimental and Computational Studies.

ABSTRACT: Okinawa propolis (OP) and its major ingredients were reported to have anti-cancer effects and lifespan-extending effects on Caenorhabditis elegans through inactivation of the oncogenic kinase, p21-activated kinase 1 (PAK1). Herein, five prenylated flavonoids from OP, nymphaeol-A (NA), nymphaeol-B (NB), nymphaeol-C (NC), isonymphaeol-B (INB), and 3'-geranyl-naringenin (GN), were evaluated for their anti-inflammatory, anti-diabetic, and anti-Alzheimer's effects using in vitro techniques. They showed significant anti-inflammatory effects through inhibition of albumin denaturation (half maximal inhibitory concentration (IC₅₀) values of 0.26⁻1.02 µM), nitrite accumulation (IC₅₀ values of 2.4⁻7.0 µM), and cyclooxygenase-2 (COX-2) activity (IC₅₀ values of 1

SUBMITTER: Shahinozzaman M 

PROVIDER: S-EPMC6222853 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature