Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter.

ABSTRACT: In traditional Asian medicinal systems, preparations of the root and stem bark of Magnolia species are widely used to treat anxiety and other nervous disturbances. The biphenyl-type neolignans honokiol and magnolol are the main constituents of Magnolia bark extracts. In the central nervous system, Magnolia bark preparations that contain honokiol are thought to primarily interact with γ-aminobutyric acid A (GABA_A) receptors. However, stress responses inherently involve the noradrenergic system, which has not been investigated in the pharmacological mechanism of honokiol. We present here interactions of honokiol and other synthesized biphenyl-type neolignans and diphenylmethane analogs with the norepinephrine transporter (NET), which is responsible for the syn

SUBMITTER: Stout K 

PROVIDER: S-EPMC6222891 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature