1-(N-Acylamino)alkyltriarylphosphonium Salts with Weakened C_α-P⁺ Bond Strength-Synthetic Applications.

ABSTRACT: The α-amidoalkylating properties of 1-(N-acylamino)alkyltriarylphosphonium salts with weakened C_α-P⁺ bond strength are discussed and examined. It is demonstrated that such type of phosphonium salts reacts smoothly with a diverse array of carbon- and heteroatom-based nucleophiles, including 1-morpholinocyclohexene, 1,3-dicarbonyl compounds, benzotriazole sodium salt, p-toluenesulfinate sodium salt, benzylamine, triarylphosphines, and other P-nucleophiles. Reactions are conducted at room temperature, in a short time (5⁻15 min) and mostly without catalysts. Simple work-up procedures result in good or very good yields of products. The structures of known compounds were established by spectroscopic methods and all new compounds have been fully characterized using ¹H-, <

SUBMITTER: Adamek J 

PROVIDER: S-EPMC6222910 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature