Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice.

ABSTRACT: Background We have reported that cytochrome P450 1B1 ( CYP 1B1), expressed in cardiovascular tissues, contributes to angiotensin II -induced vascular smooth muscle cell ( VSMC ) migration and proliferation and development of hypertension in various experimental animal models via generation of reactive oxygen species. This study was conducted to determine the contribution of CYP 1B1 to platelet-derived growth factor-BB-induced VSMC migration and proliferation in vitro and to neointimal growth in vivo. Methods and Results VSMC s isolated from aortas of male Cyp1b1 ^+/+ and Cyp1b1 ^-/- mice were used for in vitro experiments. Moreover, carotid arteries of Cyp1b1 ^+/+ and Cyp1b1 ^-/- mice were injured with a metal wire to assess neointimal growth after 1

SUBMITTER: Mukherjee K 

PROVIDER: S-EPMC6222936 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature