Carbon Nanotube Strain Sensor Based Hemoretractometer for Blood Coagulation Testing.

ABSTRACT: Coagulation monitoring is essential for perioperative care and thrombosis treatment. However, existing assays for coagulation monitoring have limitations such as a large footprint and complex setup. In this work, we developed a miniaturized device for point-of-care blood coagulation testing by measuring dynamic clot retraction force development during blood clotting. In this device, a blood drop was localized between a protrusion and a flexible force-sensing beam to measure clot retraction force. The beam was featured with micropillar arrays to assist the deposition of carbon nanotube films, which served as a strain sensor to achieve label-free electrical readout of clot retraction force in real time. We characterized mechanical and electrical properties of the force-sensing beam and optim

SUBMITTER: Li Z 

PROVIDER: S-EPMC6223013 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature