A novel, flexible and automated manufacturing facility for cell-based health care products: Tissue Factory.

ABSTRACT:

Introduction

Current production facilities for Cell-Based Health care Products (CBHPs), also referred as Advanced-Therapy Medicinal Products or Regenerative Medicine Products, are still dependent on manual work performed by skilled workers. A more robust, safer and efficient manufacturing system will be necessary to meet the expected expansion of this industrial field in the future. Thus, the 'flexible Modular Platform (fMP)' was newly designed to be a true "factory" utilizing the state-of-the-art technology to replace conventional "laboratory-like" manufacturing methods. Then, we built the Tissue Factory as the first actual entity of the fMP.

Methods

The Tissue Factory was designed based on the fMP in which several automated modules are combined to perform various culture p

SUBMITTER: Kikuchi T 

PROVIDER: S-EPMC6223031 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature