LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.

ABSTRACT:

Background

The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show changes to their epigenome, such as alterations in DNA methylation and histone methylation and acetylation landscapes. We previously showed a correlation between high Cdc42 activity in aged HSCs and the loss of intranuclear epigenetic polarity, or epipolarity, as indicated by the specific distribution of H4K16ac.

Results

Here, we show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs. Increasing the levels of H4K16ac is not sufficient to restore polarity in aged HSCs and the restoration of HSC function. The c

SUBMITTER: Grigoryan A 

PROVIDER: S-EPMC6223039 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature