Determinants of the urinary and serum metabolome in children from six European populations.

ABSTRACT:

Background

Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environment-health interactions. However, large-scale metabolome studies in children combining analyses of these biological fluids are lacking. Here, we sought to characterise the major determinants of the child metabolome and to define metabolite associations with age, sex, BMI and dietary habits in European children, by exploiting a unique biobank established as part of the Human Early-Life Exposome project ( http://www.projecthelix.eu ).

Methods

Metabolic phenotypes of matched urine and serum samples from 1192 children (aged 6-11) recruited from birth cohorts in si

SUBMITTER: Lau CE 

PROVIDER: S-EPMC6223046 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature