GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas.

ABSTRACT:

Background

Bioenergetic characterisation of malignant tissues revealed that different tumour cells can catabolise multiple substrates as salvage pathways, in response to metabolic stress. Altered metabolism in gliomas has received a lot of attention, especially in relation to IDH mutations, and the associated oncometabolite D-2-hydroxyglutarate (2-HG) that impact on metabolism, epigenetics and redox status. Astrocytomas and oligodendrogliomas, collectively called diffuse gliomas, are derived from astrocytes and oligodendrocytes that are in metabolic symbiosis with neurons; astrocytes can catabolise neuron-derived glutamate and gamma-aminobutyric acid (GABA) for supporting and regulating neuronal functions.

Methods

Metabolic characteristics of human glioma cell models - inclu

SUBMITTER: Hujber Z 

PROVIDER: S-EPMC6223071 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature