Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis.

ABSTRACT:

Background

It is unclear to what extent pre-clinical studies in genetically homogeneous animal models of amyotrophic lateral sclerosis (ALS), an invariably fatal neurodegenerative disorder, can be informative of human pathology. The disease modifying effects in animal models of most therapeutic compounds have not been reproduced in patients. To advance therapeutics in ALS, we need easily accessible disease biomarkers which can discriminate across the phenotypic variants observed in ALS patients and can bridge animal and human pathology. Peripheral blood mononuclear cells alterations reflect the rate of progression of the disease representing an ideal biological substrate for biomarkers discovery.

Methods

We have applied TMTcalibrator™, a novel tissue-enhanced bio fluid mass

SUBMITTER: Zubiri I 

PROVIDER: S-EPMC6223075 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature