The Probiotic Effectiveness in Preventing Experimental Colitis Is Correlated With Host Gut Microbiota.

ABSTRACT: Current evidence to support extensive use of probiotics in inflammatory bowel disease is limited and factors that contribute to the inconsistent effectiveness of clinical probiotic therapy are not completely known. Here, we used Bifidobacterium longum JDM 301 as a model probiotic to study potential factors that may influence the effect of probiotics in experimental colitis. We found that the effect of B. longum JDM 301 in tempering experimental colitis varied across individual mice even with the same genetic background. The probiotic efficacy was highly correlated with the host gut microbial community features. Consumption of a diet rich in fat could exacerbate mucosal injury-induced colitis but could not change the host responsiveness to B. longum JDM 301 treatment, s

SUBMITTER: Suwal S 

PROVIDER: S-EPMC6223222 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature