The effects of normovolemic anemia and blood transfusion on cerebral microcirculation after severe head injury.

ABSTRACT:

Background

Cerebral regional microcirculation is altered following severe head injury. In addition to tissue disruption, partial pressure of tissue oxygenation is impaired due to an increase in the oxygen tissue gradient. The heterogenic distribution of cerebral microcirculation is multifactorial, and acute anemia challenges further the delivery of oxygen to tissues. Currently, a restrictive transfusion threshold is globally applied; however, it is unclear how anemia modifies regional cerebral microcirculation; hence, it is unclear if by aiming to a global endpoint, specific anatomical regions undergo ischemia. This study aims to quantify the temporal changes in cerebral microcirculation after severe head injury, under the effect of anemia and transfusion. It also aims to assess it

SUBMITTER: Bellapart J 

PROVIDER: S-EPMC6223395 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature