Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database.

ABSTRACT:

Background

Maintenance of mean arterial pressure (MAP) at levels sufficient to avoid tissue hypoperfusion is a key tenet in the management of distributive shock. We hypothesized that patients with distributive shock sometimes have a MAP below that typically recommended and that such hypotension is associated with increased mortality.

Methods

In this retrospective analysis of the Medical Information Mart for Intensive Care (MIMIC-III) database from Beth Israel Deaconess Medical Center, Boston, USA, we included all intensive care unit (ICU) admissions between 2001 and 2012 with distributive shock, defined as continuous vasopressor support for ≥ 6 h and no evidence of low cardiac output shock. Hypotension was evaluated using five MAP thresholds: 80, 75, 65, 60 and 55 mmHg. We e

SUBMITTER: Vincent JL 

PROVIDER: S-EPMC6223403 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature