Impact of Geographic Regions on Overall Survival in Patients With Metastatic Renal Cell Carcinoma: Results From an International Clinical Trials Database.

ABSTRACT:

Purpose

Health determinants vary according to geographic region and may affect the outcomes of patients with metastatic renal cell carcinoma (mRCC) treated during clinical trials of targeted therapy. Here, we investigate the overall survival (OS) of patients with mRCC treated in the era of targeted therapy by geographic region.

Methods

We conducted a pooled analysis of patients with mRCC who were treated during phase II or III clinical trials. Clinical characteristics and survival data were collected. Statistical analyses were performed with the Kaplan-Meier method and log-rank test in univariable analysis.

Results

Overall, 4,736 patients were included in the analysis. Patient characteristics differed according to geographic region. No statistically significant differ

SUBMITTER: Fay AP 

PROVIDER: S-EPMC6223429 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature