Pooled Analysis of Nine Cohorts Reveals Breast Cancer Risk Factors by Tumor Molecular Subtype.

ABSTRACT: Various subtypes of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR), and HER2 exhibit etiologic differences in reproductive factors, but associations with other risk factors are inconsistent. To clarify etiologic heterogeneity, we pooled data from nine cohort studies. Multivariable, joint Cox proportional hazards regression models were used to estimate HRs and 95% confidence intervals (CI) for molecular subtypes. Of 606,025 women, 11,741 invasive breast cancers with complete tissue markers developed during follow-up: 8,700 luminal A-like (ER⁺ or PR⁺/HER2^-), 1,368 luminal B-like (ER⁺ or PR⁺/HER2⁺), 521 HER2-enriched (ER^-/PR^-/HER2⁺), and 1,152 triple-negative (ER

SUBMITTER: Gaudet MM 

PROVIDER: S-EPMC6223627 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature