Abnormal subcortical activity in congenital mirror movement disorder with RAD51 mutation.

ABSTRACT:

Purpose

Congenital mirror movement disorder (CMMD) is characterized by unintended, nonsuppressible, homologous mirroring activity contralateral to the movement on the intended side of the body. In healthy controls, unilateral movements are accompanied with predominantly contralateral cortical activity, whereas in CMMD, in line with the abnormal behavior, bilateral cortical activity is observed for unilateral motor tasks. However, task-related activities in subcortical structures, which are known to play critical roles in motor actions, have not been investigated in CMMD previously.

Methods

We investigated the functional activation patterns of the motor components in CMMD patients. By using linkage analysis and exome sequencing, common mutations were revealed in seven affecte

SUBMITTER: Demirayak P 

PROVIDER: S-EPMC6223827 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature