The Safety of Fecal Microbiota Transplantation for Crohn's Disease: Findings from A Long-Term Study.

ABSTRACT:

Introduction

Fecal microbiota transplantation (FMT) has been used as a potential treatment option for Crohn's disease (CD). However, there is still lack of safety and efficacy evidence based on large samples of CD undergoing FMT. This study aimed to evaluate the risk factors of adverse event (AE) in the long term and the efficacy of FMT in the short term for patients with CD.

Methods

FMT via mid-gut for mild to severe CD in a single center trial (NCT01793831) was performed from October 2012 to December 2016. The possible factors with AE and efficacy after FMT were prospectively recorded.

Results

A total of 184 frequencies of FMT were performed for 139 patients who received FMT. During 1 month after FMT, 13.6% of mild AEs occurred, including increased frequency of defe

SUBMITTER: Wang H 

PROVIDER: S-EPMC6223988 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature