Vulnerable combinations of functional dopaminergic polymorphisms to late-onset treatment resistant schizophrenia.

ABSTRACT:

Background

A significant portion of patients with schizophrenia who respond to initial antipsychotic treatment acquire treatment resistance. One of the possible pathogeneses of treatment-resistant schizophrenia (TRS) is antipsychotic-induced dopamine supersensitivity psychosis (Ai-DSP). Patients with this disease progression might share some genetic vulnerabilities, and thus determining individuals with higher risks of developing Ai-DSP could contribute to preventing iatrogenic development of TRS. Therefore, we decided to examine whether combinations of functional single nucleotide polymorphisms (SNPs) known to affect dopaminergic functions are related to Ai-DSP development.

Methods

In this case-control study, 357 Japanese participants diagnosed with schizophrenia or schizoa

SUBMITTER: Oishi K 

PROVIDER: S-EPMC6224074 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature