A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer.

ABSTRACT: Computed tomography (CT) is the standard imaging test used for the screening and assessment of suspected lung cancer, but distinguishing malignant from benign nodules by CT is an ongoing challenge. Consequently, a large number of avoidable invasive procedures are performed on patients with benign nodules in order to exclude malignancy. Improving cancer discrimination by non-invasive imaging could reduce the need for invasive diagnostics. In this work we focus on developing a gold nanoparticle contrast agent that targets the epidermal growth factor receptor (EGFR), which is expressed on the cell surface of most lung adenocarcinomas. Three different contrast agents were compared for their tumor targeting effectiveness: non-targeted nanoparticles, nanoparticles conjugated with full-sized anti

SUBMITTER: Ashton JR 

PROVIDER: S-EPMC6224087 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature