Correlation of Synaptic Inputs in the Visual Cortex of Awake, Behaving Mice.

ABSTRACT: The subthreshold mechanisms that underlie neuronal correlations in awake animals are poorly understood. Here, we perform dual whole-cell recordings in the visual cortex (V1) of awake mice to investigate membrane potential (Vm) correlations between upper-layer sensory neurons. We find that the membrane potentials of neighboring neurons display large, correlated fluctuations during quiet wakefulness, including pairs of cells with disparate tuning properties. These fluctuations are driven by correlated barrages of excitation followed closely by inhibition (∼5-ms lag). During visual stimulation, low-frequency activity is diminished, and coherent high-frequency oscillations appear, even for non-preferred stimuli. These oscillations are generated by alternating excitatory and inhibitory inputs a

SUBMITTER: Arroyo S 

PROVIDER: S-EPMC6224163 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature