Associations of Common Genetic Variants on IL-17 Genes and Carotid Intima-Media Thickness.

ABSTRACT:

Aim

Atherosclerosis is a chronic inflammatory process of the arterial wall and carotid intima-media thickness (cIMT) is regarded as its early marker. Several members of the IL-17 family are involved in pro-inflammatory functions. The specific aim of the study was to explore the relationships of common genetic variants on IL-17 genes with cIMT thickening.

Methods

In the discovery stage, 146 SNPs on 11 IL-17 genes were screened for their relationships with cIMT by a case-control study that enrolled 284 and 464 subjects who had thicker and normal cIMT, respectively. Findings were replicated by an independent case-control study that enrolled 282 subjects who had thicker cIMT and 282 age-sex-matched subjects who had normal cIMT.

Results

Among 134 eligible SNPs in the disco

SUBMITTER: Wu TW 

PROVIDER: S-EPMC6224208 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature