Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufiency.

ABSTRACT: Two of the most prevalent ovarian diseases affecting women's fertility and health are Primary Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). Previous studies have shown that exposure to a number of environmental toxicants can promote the epigenetic transgenerational inheritance of ovarian disease. In the current study, transgenerational changes to the transcriptome and epigenome of ovarian granulosa cells are characterized in F3 generation rats after ancestral vinclozolin or DDT exposures. In purified granulosa cells from 20-day-old F3 generation females, 164 differentially methylated regions (DMRs) (P < 1 x 10^-6) were found in the F3 generation vinclozolin lineage and 293 DMRs (P < 1 x 10^-6) in the DDT lineage, compared to controls. Long noncodin

SUBMITTER: Nilsson E 

PROVIDER: S-EPMC6224216 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature