Increased environmental temperature normalizes energy metabolism outputs between normal and Ames dwarf mice.

ABSTRACT: Ames dwarf (Prop1^df) mice possess a loss-of-function mutation that results in deficiency of growth hormone, prolactin, and thyroid-stimulating hormone, as well as exceptional longevity. Work in other laboratories suggests that increased respiration and lipid utilization are important for maximizing mammalian longevity. Interestingly, these phenotypes are observed in Ames dwarf mice. We recently demonstrated that Ames dwarf mice have hyperactive brown adipose tissue (BAT), and hypothesized that this may in part be due to their increased surface to mass ratio leading to increased heat loss and an increased demand for thermogenesis. Here, we used increased environmental temperature (eT) to interrogate this hypothesis. We found that increased eT diminished BAT activity in Ame

SUBMITTER: Darcy J 

PROVIDER: S-EPMC6224234 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature