Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression.

ABSTRACT: The paramount role of senescent cells in ageing has prompted suggestions that re-expression of telomerase may prevent ageing; a proposition that is predicated on the assumption that senescent cells are the sole cause of ageing. Recently, several DNA methylation-based age estimators (epigenetic clocks) have been developed and they revealed that increased epigenetic age is associated with a host of age-related conditions, and is predictive of lifespan. Employing these clocks to measure epigenetic age in vitro, we interrogated the relationship between epigenetic ageing and telomerase activity. Although hTERT did not induce any perceptible change to the rate of epigenetic ageing, hTERT-expressing cells, which bypassed senescence, continued to age epigenetically. Employment of hTERT muta

SUBMITTER: Kabacik S 

PROVIDER: S-EPMC6224244 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature