Quantitative characterization of biological age and frailty based on locomotor activity records.

ABSTRACT: We performed a systematic evaluation of the relationships between locomotor activity and signatures of frailty, morbidity, and mortality risks using physical activity records from the 2003-2006 National Health and Nutrition Examination Survey (NHANES) and UK BioBank (UKB). We proposed a statistical description of the locomotor activity tracks and transformed the provided time series into vectors representing physiological states for each participant. The Principal Component Analysis of the transformed data revealed a winding trajectory with distinct segments corresponding to subsequent human development stages. The extended linear phase starts from 35-40 years old and is associated with the exponential increase of mortality risks according to the Gompertz mortality law. We characterized th

SUBMITTER: Pyrkov TV 

PROVIDER: S-EPMC6224248 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature