Model-Based Analysis of Electrode Placement and Pulse Amplitude for Hippocampal Stimulation.

ABSTRACT:

Objective

The ideal form of a neural-interfacing device is highly dependent upon the anatomy of the region with which it is meant to interface. Multiple-electrode arrays provide a system that can be adapted to various neural geometries. Computational models of stimulating systems have proven useful for evaluating electrode placement and stimulation protocols, but have yet to be adequately adapted to the unique features of the hippocampus.

Methods

As an approach to understanding potential memory restorative devices, an admittance method-NEURON model was constructed to predict the direct and synaptic response of a region of the rat dentate gyrus to electrical stimulation of the perforant path.

Results

A validation of estimated local field potentials against experimental

SUBMITTER: Bingham CS 

PROVIDER: S-EPMC6224291 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature