Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling.

ABSTRACT: In humans, depression is often associated with low-grade inflammation, activation of the tryptophan/kynurenine pathway, and mild lymphopenia. Preclinical research confirms that inflammation induces depression-like behavior through activation of the tryptophan/kynurenine pathway. However, the mechanisms governing recovery from depression are unknown. Understanding the pathways leading to resolution of depression will likely lead to identification of novel targets for treatment. We investigated the contribution of T lymphocytes to the resolution of lipopolysaccharide-induced depression-like behavior. Duration of depression-like behavior was markedly prolonged in mice without mature T or B lymphocytes (Rag1^-/- mice). This prolonged depression-like behavior was associated with persi

SUBMITTER: Laumet G 

PROVIDER: S-EPMC6224384 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature