Serum Amyloid A3 is required for normal lung development and survival following influenza infection.

ABSTRACT: Serum amyloid A (SAA) proteins are a family of acute phase apolipoproteins implicated to directly modulate innate and adaptive immune responses. However, new studies comparing endogenous SAAs and recombinant forms of these proteins have questioned the function of SAA in inflammation and immunity. We generated SAA3 knockout mice to evaluate the contribution of SAA3 to lung development and immune-mediated lung disease. While SAA3 deficiency does not affect the generation of house dust mite-induced allergic asthma, mice lacking SAA3 develop adult-onset obesity, intrinsic airway hyperresponsiveness, increased inflammatory and fibrotic gene expression in the lung, and elevated levels of lung citrullinated proteins. Polyclonally stimulated CD4⁺ T cells from SAA3-/- mice exhibit impair

SUBMITTER: Ather JL 

PROVIDER: S-EPMC6224415 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature